Journal of Cancer Prevention

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Fig. 2.

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Fig. 2. Cytosolic iron chaperon systems. Iron is incorporated by binding of transferrin to transferrin receptor into the cellular cytosol through late endosome/lysosome. Iron retrieved and reduced by STEAP3 (six-transmembrane epithelial antigen of the prostate 3) to Fe(II) in late endosome/lysosome goes through divalent metal transporter 1 (DMT1) (solute carrier family 11 member 2 [SLC11A2]) to cytosol, where Fe(II) is immediately chaperoned by poly rC binding protein 2 (PCBP2). PCBP1 is another Fe(II) chaperone, competing each other. PCBP1 can load iron to ferritin, where Fe(II) is oxidized to Fe(III) via ferritin heavy chain (FTH). PCBP2 appears to play wider roles in transporting Fe(II) in the cytosol. If Fe(II) is not chaperoned by PCBP1/2 due to pathologic causes, unchaperoned Fe(II) is catalytic. Red filled circle, Fe(II); blue filled circle, Fe(III). Note that Fe(III) is insoluble at neutral pH.
J Cancer Prev 2021;26:244~249
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