Journal of Cancer Prevention

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Fig. 3.

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Fig. 3. Summary of effects of PM10 and PM2.5 exposure on skin. The scheme illustrates the associated biological signaling pathways followed by expression changes of the key regulators expected during skin exposure to PM10 & PM2.5. This model provides the potential biological mechanisms differentiated by exposure and size of PMs. TP53, tumor protein p53; FN1, fibronectin 1; CSF2, colony stimulating factor 2; PPARG, peroxisome proliferator activated receptor gamma; EGFR, EGF receptor; JUN, jun proto-oncogene; ICAM1, intercellular adhesion molecule 1; CCL2, CC motif chemokine ligand 2; FGF2, fibroblast growth factor 2; VEGFA, vascular endothelial growth factor A.
J Cancer Prev 2021;26:153~161
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