Journal of Cancer Prevention

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Fig. 6.

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Fig. 6. DATS arrested cells at G2 as well as mitotic phase in human breast cancer cells. (A) Representative propidium iodide (PI) histogram displaying 2 N and 4 N DNA content in MCF-7 and MDA-MB-231 cells after 8-hour treatment with DMSO (control) or 20 mmol/L DATS. (B) Quantification of the percentage of cells at G2 and M phases in MCF-7 and MDA-MB-231 cells treated with DMSO (control) or indicated doses of DATS for 4 or 8 hours. Results shown are mean ± SD (n = 3) and statistical analysis was done by one-way ANOVA followed by Dunnett’s test (*P < 0.05). (C) Representative cell cycle histogram of DNA stained with PI and mitotic marker in MCF-7 and MDA-MB-231 cells after 8-hour treatment with DMSO (control) or 20 µmol/L DATS. (D) Quantification of the percentage of cells undergoing mitosis in MCF-7 and MDA-MB-231 cells treated with DMSO (control) or indicated doses of DATS for 4 or 8 hours. Results shown are mean ± SD (n = 3) and statistical analysis was done by one-way ANOVA followed by Dunnett’s test (*P < 0.05). DATS, diallyl trisulfide; MCF-7, michigan cancer foundation-7; MDA-MB-231, MD anderson-metastatic breast-231; DMSO, dimethyl sulfoxide.
J Cancer Prev 2021;26:128~136 https://doi.org/10.15430/JCP.2021.26.2.128
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