Journal of Cancer Prevention

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Fig. 3.

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Fig. 3. Heregulin-β1-induced nuclear translocation of NF-E2-related factor 2 (Nrf2) is mediated by extracellular signal-regulated protein kinase (ERK) and protein kinase B (Akt). (A, B) MCF-7 cells were preincubated with U0126 (5 μM) or LY294002 (20 μM) and exposed to heregulin-β1 (50 ng/mL) for 8 hours for immunofluorescence (A) and Western blot (B) analyses of Nrf2. Scale bar, 100 μm. (C) Effects of dominant negative mutant Nrf2 on manganese superoxide dismutase (MnSOD) expression.
J Cancer Prev 2021;26:54~63
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