Journal of Cancer Prevention

eISSN 2288-3657
pISSN 2288-3649

List of significantly changed metabolites in the bile acid pathway

Metabolites Biochemical pathways Metabolites Fold control

A/WT AF/WT
Mucosa Primary bile acid metabolism Cholate sulfate 0.05b 0.25b
Plasma Secondary bile acid metabolism Deoxycholate 3.19a 2.03a

A/WT AF/WT AF/A

Mucosa Primary bile acid metabolism Cholate 1.33 4.49a 3.38a
Chenodeoxycholate 1.13 4.95a 4.37a
Beta-muricholate 0.86 2.68a 3.11a
Secondary bile acid metabolism Deoxycholate 3.02a 7.65a 2.53a
Taurodeoxycholate 2.75 6.29a 2.28a
6-beta-hydroxylithocholate 2.1a 4.29a 2.05a
7-ketolithocholate 5.92a 11.94a 2.02a
Hyocholate 0.84 3.55a 4.23a
3-dehydrocholate 1.11 3.1a 2.8a
7-ketodeoxycholate 0.9 3.83a 4.24a

Fold change is calculated as the ratio of the ApcMin/+ (A) vs. WT, ApcMin/+-Ffar2-/- (AF) vs. WT, and ApcMin/+-Ffar2-/- vs. ApcMin/+. Fold change that is labeled a or b presents significantly increased or significantly decreased, respectively. WT, wild-type. P < 0.05.

J Cancer Prev 2021;26:32~40 https://doi.org/10.15430/JCP.2021.26.1.32
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