Journal of Cancer Prevention

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Fig. 3.

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Fig. 3. The effect of CRUs and APIs on development of colonic ACF in mice fed PhIP as a carcinogen at two different dietary concentrations. (A) Representative image of ACF in distal colon of A/J mice after staining with methylene blue (arrow; 40 × magnification). (B) Effect of TWD and API- or CRU-containing TWD on ACF in the low PhIP-treated groups (bright grey) and in the high PhIP-treated groups (dark grey). Values are presented as mean ± SEM; n = 8. Within a parameter, bars that do not share a letter are significantly different (P < 0.05) as determined by two-way ANOVA with the Duncan’s post-hoc test. There were statistically significant main effects of diet (P < 0.031) and PhIP (P < 0.001) and a statistically significant interaction (P = 0.0007). ACF, aberrant crypt foci; TWD, total Western diet; CRU, cruciferous vegetable; API, apiaceous vegetable; PhIP, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine.
J Cancer Prev 2020;25:223~233
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