Journal of Cancer Prevention

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Fig. 6.

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Fig. 6. Diallyl trisulfide (DATS) administration inhibits phosphorylation of STAT3 at Ser-727 in SUM159 xenografted mice and shows no signs of toxicity in N-methyl-N-nitrosourea (MNU)-induced Sprague–Dawley rats. (A) Immunoblots showing protein levels of P-STA3 (S727), P-STAT3 (Y705), and total STAT3 using tumor lysates from SUM159 xenografts. (B) The bar graph shows quantitation of immunoreactive bands for P-STAT3 (S727), P-STAT3 (Y705), and total STAT3. Results shown are mean ± SD (n=5 for control group and n=4 for DATS treatment group). Statistical analysis was performed by unpaired Student’s t-test. (C) Body weight over time in MNU-injected rats fed vehicle (control) or DATS (5 or 25 mg/kg body weight). Results shown are mean ± SD (n = 21 for control, n = 20 for 5 mg/kg DATS, and n = 20 for 25 mg/kg DATS). Statistical analysis was performed by one-way ANOVA followed by Dunnett’s test. (D) Palpable mammary tumor incidence over time in MNU-injected rats fed vehicle or DATS (5 or 25 mg/kg body weight). Statistical analysis was performed by Fisher’s exact test.
Journal of Cancer Prevention 2020;25:1~12 https://doi.org/10.15430/JCP.2020.25.1.1
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