Journal of Cancer Prevention

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Fig. 3.

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Fig. 3.

A putative adverse outcome (AO) pathway (AOP) related to sulfuric acid mists carcinogenicity. Upper panel: An AOP framework that consists of a molecular initiating event (MIE) leading to an adverse outcome through the key events (KEs) at various biological levels (ranging from cells to organ systems) and these KE relationships. Lower panel: The MIE cause a low pH, which can result in acute or chronic abnormal biological states. Based on the putative AOP, a possible mechanism of genetic instability relates to low pH, which can induce tumorigenesis or carcinogenesis.

J Cancer Prev 2019;24:139~145
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