Journal of Cancer Prevention

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Fig. 1. Catalytic cycle of peroxiredoxin (Prx) isoforms. (A) Typical 2-Cys Prxs (Prx1-4) first mediate the oxidation of CP residues to sulfenic acid by H2O2, followed by the formation of an intermolecular disulfide bond with the CR of another Prx subunit. Lastly, the oxidized Prx undergoes reduction by the thioredoxin (Trx)/Trx reductase (TrxR)/NADPH system. (B) Atypical 2-Cys Prx (Prx5) is similar to typical 2-Cys Prxs, except that they mediate the formation of an intramolecular disulfide bond with the CR of the same Prx subunit. (C) 1-Cys Prx (Prx6) has only one conserved Cys residue so that they are recycled in sulfenic acid without forming a disulfide bond, which is reduced by glutathione (GSH) instead of Trx.
Journal of Cancer Prevention 2019;24:65~71
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