eISSN 2288-3657
pISSN 2288-3649
pISSN 2288-3649
Components of AOP 220
| Component | Description |
|---|---|
| MIE | Activation of CYP2E1 in the liver |
| KE1 | Oxidative stress |
| KE2 | Hepatocytotoxicity |
| KE3 | Hepatocellular regenerative proliferation |
| AO | Liver cancer |
| KER1 | Activation of CYP2E1 in the liver leads to oxidative stress |
| KER2 | Oxidative stress leads to hepatocytotoxicity |
| KER3 | Hepatocytotoxicity leads to hepatocellular regenerative proliferation |
| KER4 | Hepatocellular regenerative proliferation leads to liver cancer |
| naKER1 (MIE to KE2) | Activation of CYP2E1 in the liver leads to hepatocytotoxicity |
| naKER2 (KE1 to AO) | Oxidative stress leads to liver cancer |
| naKER3 (KE2 to AO) | Hepatocytotoxicity leads to liver cancer |
AOP, adverse outcome pathway; MIE, molecular initiating event; KE, key event; AO, adverse outcome; KER, key event relationship.
Journal of Cancer Prevention 2018;23:126~133 https://doi.org/10.15430/JCP.2018.23.3.126
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