Journal of Cancer Prevention

eISSN 2288-3657
pISSN 2288-3649
Fig. 1.

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Fig. 1. The preventive effect of docosahexaenoic acid (DHA) against pancreatic cancer development. In pancreatic cancer cells, DHA induces glutathione (GSH) extrusion which increases the levels of reactive oxygen species (ROS) and caspase activation, resulting in ROS-mediated apoptosis. DHA also inhibits activation of Wnt/β-catenin signaling by increasing binding of glycogen synthase kinase-3β (GSK3β) to axin and reducing β-catenin accumulation as well as expression of cyclin E. Thus, DHA suppresses cancer cell proliferation. DHA down-regulates gran-zyme B, which degrades extracellular matrix (ECM) and promotes cancer cell invasion. DHA also reduces pro-angiogenic factors, such as VEGF and platelet-derived growth factor (PDGF). Therefore, DHA may inhibit resistance to cancer therapies and cancer development, and increase survival rate of pancreatic cancer patients.
Journal of Cancer Prevention 2017;22:1~5 https://doi.org/10.15430/JCP.2017.22.1.1
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