Journal of Cancer Prevention

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Fig. 3.

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Fig. 3. Effects of normal diet (ND) and high-fat diet (HFD) on intestinal permeability and colonic tight junction (TJ) protein levels in APCmin/+ mice. APCmin/+ mice were fed either ND or HFD for 12 weeks. (A) Intestinal permeability was assessed by measuring blood fluorescein isothiocyanate (FITC)-dextran level after gavage FITC-dextran (600 mg/kg body weight). Colonic expressions of tight junction proteins, (B) occludin, (C) claudin-1, and (D) zonula occludens-1 (ZO-1), were evaluated by Western blotting. Graph shows ratios of the intensities of TJ protein bands normalized with that of β-actin band. Values are expressed as mean ± SD (n = 10). *Significant (P < 0.05).
Journal of Cancer Prevention 2016;21:95~103
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