Journal of Cancer Prevention

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Fig. 5.

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Fig. 5. The hypothetical scheme of a mechanism in which carnosic acid (CA) inhibits lipid accumulation in 3T3-L1 adipocytes. CA effectively inhibits lipid accumulation in differentiating 3T3-L1 adipocytes by blocking adipocyte-associated gene expression and glycerol 3-phosphate dehydrogenase (GPDH) activity, leading to changes in fatty acid composition. PPARγ, peroxisome proliferator-activated receptor-γ; C/EBPα, CCAAT/enhancer binding protein-α; SREBP1, sterol regulatory element-binding protein 1; TG, triglycerides; SCD1, stearoyl CoA desaturase 1; DHAP, dihydroxyacetone phosphate; C16:1, palmitoleate; C18:1, oleate.
Journal of Cancer Prevention 2015;20:41~49
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