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Plasma Adropin as a Potential Marker Predicting Obesity and Obesity-associated Cancer in Korean Patients With Type 2 Diabetes Mellitus
Journal of Cancer Prevention 2018;23:191-6
Published online December 30, 2018
© 2018 Korean Society of Cancer Prevention.

Ha-Neul Choi, and Jung-Eun Yim

Department of Food and Nutrition, College of Natural Science, Changwon National University, Changwon, Korea
Correspondence to: Jung-Eun Yim
Department of Food and Nutrition, College of Natural Science, Changwon National University, 20 Changwondaehak-ro, Uichang-gu, Changwon 51140, Korea
Tel: +82-55-213-3517, Fax: +82-55-281-7480, E-mail:
ORCID: Jung-Eun Yim,
Received November 19, 2018; Revised December 17, 2018; Accepted December 18, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Type 2 diabetes mellitus (T2DM) and cancer are serious health problems worldwide, and their prevalences have been on the rise in recent years. It has been reported that adropin plays an important role in the development of T2DM, oxidative stress, inflammation, and obesity. However, there is limited information available on T2DM from human studies, especially for the Korean population. In this study, we aimed to investigate the correlation between adropin levels and obesity of Korean T2DM patients.
Methods: Thirty-six T2DM patients were recruited for this study. The participants were further classified into female (n = 12) and male (n = 24). Their body composition, metabolic parameters, inflammatory factors, and oxidative stress were measured.
Results: The severity of obesity is more manifested in male than in female. Plasma triglyceride (TG) and high-sensitivity C-reactive protein (hs-CRP) levels of male were significantly higher than female. The plasma adropin and adiponectin level of female was significantly higher than male. The body weight, body mass index (BMI), body fat mass were negatively correlated with the plasma adropin level in female, whereas adropin has positive correlation with adiponectin in female. The hs-CRP was negatively correlated with the plasma adropin level in female and male. malondialdehyde, reactive oxidative species, and TNF-α was not significantly correlated with adropin in patients with T2DM.
Conclusions: These findings suggest that adropin may be more used as a biomarker for predicting the risk of obesity and inflammation in Korean patients with T2DM, especially women.
Keywords : Diabetes mellitus, Obesity, Adropin, Inflammation, Oxidative stress

December 2018, 23 (4)
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