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Validation of Administrative Big Database for Colorectal Cancer Searched by International Classification of Disease 10th Codes in Korean: A Retrospective Big-cohort Study
Journal of Cancer Prevention 2018;23:183-90
Published online December 30, 2018
© 2018 Korean Society of Cancer Prevention.

Young-Jae Hwang1, Nayoung Kim1,4,5, Chang Yong Yun1, Hyuk Yoon1, Cheol Min Shin1, Young Soo Park1, Il Tae Son2, Heung-Kwon Oh2, Duck-Woo Kim2, Sung-Bum Kang2, Hye Seung Lee3, Seon Mee Park6, and Dong Ho Lee1,4,5

Departments of 1Internal Medicine, 2Surgery, and 3Pathology, Seoul National University Bundang Hospital, Seongnam, 4Department of Internal Medicine and Institute of Liver Research, Seoul National University College of Medicine, 5Tumor Microenvironment Global Core Research Center, Seoul National University, Seoul, 6Department of Internal Medicine, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Korea
Correspondence to: Nayoung Kim
Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam 13620, Korea
Tel: +82-31-787-7008, Fax: +82-31-787-4051, E-mail:
ORCID: Nayoung Kim,
Received December 2, 2018; Revised December 14, 2018; Accepted December 18, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: As the number of big-cohort studies increases, validation becomes increasingly more important. We aimed to validate administrative database categorized as colorectal cancer (CRC) by the International Classification of Disease (ICD) 10th code.
Methods: Big-cohort was collected from Clinical Data Warehouse using ICD 10th codes from May 1, 2003 to November 30, 2016 at Seoul National University Bundang Hospital. The patients in the study group had been diagnosed with cancer and were recorded in the ICD 10th code of CRC by the National Health Insurance Service. Subjects with codes of inflammatory bowel disease or tuberculosis colitis were selected for the control group. For the accuracy of registered CRC codes (C18-21), the chart, imaging results, and pathologic findings were examined by two reviewers. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for CRC were calculated.
Results: A total of 6,780 subjects with CRC and 1,899 control subjects were enrolled. Of these patients, 22 subjects did not have evidence of CRC by colonoscopy, computed tomography, magnetic resonance imaging, or positron emission tomography. The sensitivity and specificity of hospitalization data for identifying CRC were 100.00% and 98.86%, respectively. PPV and NPV were 99.68% and 100.00%, respectively.
Conclusions: The big-cohort database using the ICD 10th code for CRC appears to be accurate.
Keywords : Database, Validation, Colorectal neoplasms, International Classification of Disease

December 2018, 23 (4)
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