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The Role of Tripartite Motif Family Proteins in TGF-β Signaling Pathway and Cancer
Journal of Cancer Prevention 2018;23:162-9
Published online December 30, 2018
© 2018 Korean Society of Cancer Prevention.

Ho-Jae Lee

Department of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Korea
Correspondence to: Ho-Jae Lee
Department of Biochemistry, Gachon University College of Medicine, 155 Gaetbeol-ro, Yeonsu-gu, Incheon 21999, Korea
Tel: +82-32-899-6054, Fax: +82-32-899-6039, E-mail:
ORCID: Ho-Jae Lee,
Received December 3, 2018; Revised December 18, 2018; Accepted December 18, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
TGF-β signaling plays a tumor suppressive role in normal and premalignant cells but promotes tumor progression during the late stages of tumor development. The TGF-β signaling pathway is tightly regulated at various levels, including transcriptional and post-translational mechanisms. Ubiquitination of signaling components, such as receptors and Smad proteins is one of the key regulatory mechanisms of TGF-β signaling. Tripartite motif (TRIM) family of proteins is a highly conserved group of E3 ubiquitin ligase proteins that have been implicated in a variety of cellular functions, including cell growth, differentiation, immune response, and carcinogenesis. Recent emerging studies have shown that some TRIM family proteins function as important regulators in tumor initiation and progression. This review summarizes current knowledge of TRIM family proteins regulating the TGF-β signaling pathway with relevance to cancer.
Keywords : Tripartite motif proteins, Transforming growth factor beta, Neoplasms

December 2018, 23 (4)
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