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Polymorphism Located in the Upstream Region of the RPS19 Gene (rs2305809) Is Associated With Cervical Cancer: A Case-control Study
Journal of Cancer Prevention 2018;23:147-52
Published online September 30, 2018
© 2018 Korean Society of Cancer Prevention.

Thaís da Rocha Boeira1, Janaina Coser2,3, Jonas Michel Wolf1, Bruna Klahr Manggini Cardinal2, Ivana Grivicich1, Daniel Simon1, Vagner Ricardo Lunge1

1Graduate Program in Cellular and Molecular Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas,
2Biomedicine Course, University of Cruz Alta (UNICRUZ), Cruz Alta, 3Graduate Program in Integral Health Care, University of Cruz Alta/Regional University of the Northwestern Rio Grande do Sul state (UNICRUZ/UNIJUÍ), Cruz Alta/Ijuí, Brazil
Correspondence to: Jonas Michel Wolf
Graduate Program in Cellular and Molecular Biology Applied to Health, Lutheran University of Brazil (ULBRA), Av. Farroupilha, 8001 - São José, Canoas - RS, 96923-101, Brazil
Tel: +55-51-34774000 (ext. 2433), Fax: +55-51-34774000 (ext. 2433), E-mail:
ORCID: Jonas Michel Wolf,
Received July 17, 2018; Revised September 21, 2018; Accepted September 21, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cervical cancer (CC) is caused by persistent human papillomavirus (HPV) infection and affects women worldwide. The progression of an HPV persistent infection to CC is influenced by genetic factors. Three single nucleotide polymorphisms (SNPs) in TP53, NQO1 and RPS19 genes (rs1042522, rs1800566, rs2305809, respectively) were previously associated with CC in European and North American populations. The present case-control study aimed to investigate the association of the SNPs rs1042522, rs1800566, and rs2305809 with CC in an admixed population in southern Brazil. A total of 435 women (106 CC patients and 329 controls) were recruited for this study. All women were interviewed and underwent clinical sampling. SNPs rs1042522 and rs1800566 were evaluated by PCR-RFLP. SNP rs2305809 was determined by real-time PCR. The crude and adjusted ORs with 95% CI were estimated. The recessive genetic model (C/C 竊 C/T) for rs2305809 was more frequent in the control group (79.9%) compared to the cases (69.8%), being associated with CC protection (adjustedOR = 0.49; 95% CI: 0.27-0.90). However, the other polymorphisms evaluated did not present significant differences between cases and controls. This study detected a protective association for the recessive genetic model in rs2305809. These results suggest a potential role of the RPS19 gene in CC.
Keywords : Cervical cancer, Single nucleotide polymorphisms, Case-control study

September 2018, 23 (3)
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