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Application of the Adverse Outcome Pathway Framework to Risk Assessment for Predicting Carcinogenicity of Chemicals
Journal of Cancer Prevention 2018;23:126-33
Published online September 30, 2018
© 2018 Korean Society of Cancer Prevention.

Doo Seok Kang1, Jun Hyuek Yang1, Hyun Soo Kim1, Bon Kon Koo1, Cheol Min Lee2, Yeon-Soon Ahn3, Jong-Hyeon Jung4, Young Rok Seo1

1Institute of Environmental Medicine for Green Chemistry, Department of Life Science, Dongguk University Biomedi Campus, Goyang, 2Department of Chemical and Biological Engineering, College of Natural Science and Engineering, Seokyeong University, Seoul, 3Department of Preventive Medicine and Institute of Occupational and Environmental Medicine, Yonsei University Wonju College of Medicine, Wonju, 4Faculty of Health Science, Daegu Haany University, Gyeongsan, Korea
Correspondence to: Young Rok Seo
Institute of Environmental Medicine for Green Chemistry, Department of Life Science, Dongguk University Biomedi Campus, 32 Dongguk-ro, Ilsandong-gu, Goyang 10326, Korea
Tel: +82-31-961-5172, E-mail: seoyr@dongguk.edu
ORCID: Young Rok Seo, https://orcid.org/0000-0002-4093-4073
Received September 11, 2018; Revised September 25, 2018; Accepted September 27, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
As industry develops in modern society, many chemicals are being used. The safety of chemicals is an important issue because humans are constantly exposed to chemicals throughout their daily life. Through a risk assessment, the hazardous human effects of chemicals can be identified. Recently, the adverse outcome pathway (AOP) framework has been used to predict the adverse effects of chemicals. As a conceptual framework for organizing existing biological knowledge, the AOP consists of a molecular initiating event, key events, and an adverse outcome. These independent elements represent biological responses and are connected by key event relationships. This AOP framework provides intuitive hazard identification that can be helpful for carcinogenic risk assessment of chemicals. In this review, we introduce the application of the AOP framework to risk assessment for predicting carcinogenicity of chemicals and illustrate the utility of this approach for cancer prevention.
Keywords : Chemical safety, Adverse outcome pathways, Carcinogenesis, Risk assessment


September 2018, 23 (3)
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