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The Effect of Microbiota on Colon Carcinogenesis
Journal of Cancer Prevention 2018;23:117-25
Published online September 30, 2018
© 2018 Korean Society of Cancer Prevention.

Kichul Yoon1,2, Nayoung Kim1,3

1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, 2Department of Internal Medicine and Digestive Disease Research Institute, Wonkwang University Sanbon Hospital, Gunpo, 3Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
Correspondence to: Nayoung Kim
Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam 13620, Korea
Tel: +82-31-787-7008, Fax: +82-31-787-4051, E-mail: nayoungkim49@empas.com, ORCID: Nayoung Kim, https://orcid.org/0000-0002-9397-0406
Received September 14, 2018; Revised September 20, 2018; Accepted September 21, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Although genetic background is known to contribute to colon carcinogenesis, the exact etiology of the disease remains elusive. The organ셲 extensive interaction with microbes necessitated research on the role of microbiota on development of colon cancer. In this review, we summarized the defense mechanism of colon from foreign organism, and germ-free animal models that have been employed to elucidate microbial effect. We also comprehensively discussed the metabolic property of microbiota such as butyrate production, facilitation of heme toxicity, bile acid transformation, and nitrate reduction that has been shown to contribute to the development of the tumor. Finally, up-to-date subjects such as the effect of age and gender on microbiota are briefly discussed.
Keywords : Microbiota, Colon, Carcinogenesis, Butyric acid, Bile acids and salts


September 2018, 23 (3)
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