Journal of Cancer Prevention

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Fig. 2. Effects of TWD and API- and CRU-containing TWD on hepatic enzymatic activities of (A) CYP1A2 and (B) UGT1A in the low PhIP-treated groups (bright grey) and in the high PhIP-treated groups (dark grey). Values are presented as mean ± SEM; n = 8. Within a parameter, bars that do not share a letter are significantly different (P < 0.05) as determined by two-way ANOVA with Duncan’s post-hoc test. (A) There were statistically significant main effects of diet (P < 0.001) and PhIP (P < 0.001) and a statistically significant interaction (P = 0.009) for hepatic CYP1A2 activity by two-way ANOVA. (B) There was a trend for a main effect of diet (P = 0.097), but no main effect of PhIP, and no interaction for hepatic UGT1A activity by two-way ANOVA. CYP, cytochrome P450; TWD, total Western diet; CRU, cruciferous vegetable; API, apiaceous vegetable; PhIP, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; UGT1A, UDP-glucuronosyltransferase 1A.
J Cancer Prev 2020;25:223~233 https://doi.org/10.15430/JCP.2020.25.4.223
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