Journal of Cancer Prevention

eISSN 2288-3657
pISSN 2288-3649

Summary of major chemopreventive agents

Agent Target Cancer prevention effect References
Selective estrogen receptor modulators Estrogen receptor (ER) Reduce ER-positive breast cancer incidence in high-risk populations 11-18
Aromatase inhibitors Aromatase Reduce ER-positive breast cancer incidence in high-risk populations 16, 19, 20
Non-steroidal anti-inflammatory drugs COX1/COX2 Reduce the occurrence of several cancers, mainly CRC and less notably stomach and esophageal cancers 21-25
Statins HMG-CoA reductase Observational studies showed long term statin use reduces incidences of gastrointestinal cancer 27-30
Metformin Gluconeogenesis Observational studies showed metformin use lowers risks of cancer incidence and mortality in diabetic patients 31-34

CRC, colorectal cancer; HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A.

J Cancer Prev 2020;25:127~135 https://doi.org/10.15430/JCP.2020.25.3.127
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