Journal of Cancer Prevention

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Fig. 1. A simplified view of the biological mechanisms of non-steroidal anti-inflammatory drugs (NSAIDs) and COX2 selective inhibitors (COXIBs). NSAIDs and COXIBs inhibit COX1/2 enzymes and block the synthesis of inflammatory prostaglandins, therefore inhibit the downstream tumor-promoting events, such as inflammation, cell proliferation, and angiogenesis, and prevent cancer initiation.
J Cancer Prev 2020;25:127~135 https://doi.org/10.15430/JCP.2020.25.3.127
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