Journal of Cancer Prevention : pISSN 2288-3649 / eISSN 2288-3657

Fig. 3.

Download original image
Fig. 3. (A, B) Upregulation of COX-2 in colitis-associated cancer as determined by (A) reverse transcription-PCR for COX-2 mRNA or (B) Western blot analysis for COX-2 protein in colonic tissues. Expression of COX-2 as well as its mRNA transcript was significantly increased in the colon of azoxymethane (AOM) plus dextran sulfate sodium (DSS) treated mice compared to the mice in the vehicle group. (C) Comparison of the relative expression of COX-2 and COX-1 and their mRNA transcripts between the vehicle group and the AOM plus DSS group. (D) Immunohistochemical staining of COX-2. Aberrantly increased expression of COX-2 was observed in infiltrated inflammatory cells and some epithelial cells surrounding the tumor (× 100). GAPDH, glyceraldegyde-3-phosphate dehydrogenase.
Journal of Cancer Prevention 2020;25:27-37
© 2020 Journal of Cancer Prevention