Journal of Cancer Prevention : pISSN 2288-3649 / eISSN 2288-3657

Fig. 3.

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Fig. 3. Effect of docosahexaenoic acid (DHA) on the expression levels of protein kinase C delta (PKC-δ) and NF-κB, and histological change in pancreas (H&E, × 400 [scale bar, 20 μm]). (A) Immunohistochemical analysis was performed using anti-PKC-δ and anti-NF-κB p65 antibodies. (a–c) Representative PKC-δ expression levels in pancreas. (a) Negligible signals of PKC-δ expression were detected in none group. (b) Intense signals of PKC-δ were detected in control group. (c) Few PKC-δ-positive cells were observed in DHA group. (d–f) Representative NF-κB p65 expression levels in pancreas. (d) Negligible signals of NF-κB p65 expression were detected in none group. (e) Intense signals of NF-κB p65 were detected in control group. (f) Few NF-κB p65-positive cells were observed in DHA group. (B) Histological changes in pancreas. (a) Healthy pancreatic tissue was observed in none group. (b) Abnormal tissue structures including leukocyte infiltration (black small asterisks), necrosis of acinar cells (white bold arrows) and vacuolization (black small arrow) were observed in control group. (c) Reduced acinar cell necrosis, inflammatory cell infiltration, and vacuolization lesions were observed in mice co-treated with cerulein and DHA. None, untreated mice; Control, mice treated with cerulein alone; DHA, mice treated with cerulein and DHA.
Journal of Cancer Prevention 2019;24:233-9 https://doi.org/10.15430/JCP.2019.24.4.233
© 2019 Journal of Cancer Prevention