Journal of Cancer Prevention : pISSN 2288-3649 / eISSN 2288-3657

Table. 1.

Table. 1.

The most frequent dysregulated miRNAs involved in the pathogenesis of medulloblastoma

miRNA Observation Functional target Representativetargeta Reference No.
miR-17/92 Up-regulated SHH pathway ZNFX1 [47]
MYCN/MYC CCL1
Gli1 GPR137B
NABP1
Let-7g Up-regulated RAS CDK6 [52]
STAT3 CDC25A
KRAS
MYC
miR-199-5p Up-regulated HES1 HES1 [50]
Notch pathway ETS2
ErbB2 MECP2
miR-214 Up-regulated SHH pathway EZH2 [53]
Gli1 PTEN
DAPK1
miR-9 Down-regulated REST/NRSF TP53INP1
t-Trk-C MMP13
REST
miR-125a Down-regulated REST/NRSF CDKN1A [54]
t-Trk-C LIN28A
TP53
LIF
miR-124a Down-regulated CDK6 SOX9 [55]
BDNF
EFNB1
miR-125b Down-regulated Smo BMPR1B [56]
Gli1 EIF4EBP1
HMGA2
miR-324-5p Down-regulated Smo SMO [57]
Gli1 GLI1
WNT9B
miR-326 Down-regulated Smo GLI1 [49]
Gli1 SMO
NOTCH1
NOTCH2
miR-218 Down-regulated EGFR MBNL2 [51]
Bcl-2 EFNA1
NUP93
EBP

The important microRNAs (miRNAs) with their pathways are considered in this table. It also provides the targeted genes of miRNAs.

miRNAs target according to miRTarBase.
Journal of Cancer Prevention 2019;24:79-90 https://doi.org/10.15430/JCP.2019.24.2.79
© 2019 Journal of Cancer Prevention