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Table. 4.

Table. 4.

Association of breast density and cancer-related risk factors on breast cancera

BI-RADS 1 and 2 (< 50%) BI-RADS 3 (5%–75%) BI-RADS 4 (≥ 75%)



No. of cases/controls OR (95% CI) No. of cases/controls OR (95% CI) P-value No. of cases/controls OR (95% CI) P-value
Age at menarche (yr)
 < 15 118/99 1 658/442 1.034 (0.763–1.401) 0.8291 502/276 1.059 (0.764–1.468) 0.7308
 ≥ 15 93/136 1 281/322 1.088 (0.788–1.501) 0.0058 123/120 1.110 (0.744–1.658) 0.0093
Age at menopause (yr)
 Premenopausal 59/42 1 548/380 1.071 (0.688–1.666) 0.7618 511/310 1.100 (0.705–1.716) 0.6746
 < 50 65/93 1 199/233 1.079 (0.709–1.643) 0.7225 69/65 1.159 (0.759–1.771) 0.4937
 ≥ 50 92/135 1 209/248 0.950 (0.640–1.408) 0.7968 51/55 0.831 (0.499–1.383) 0.4755
Number of children
 0 10/10 1 146/60 2.413 (0.924–6.299) 0.072 143/72 1.488 (0.567–3.905) 0.4189
 1 30/32 1 175/127 1.042 (0.583–1.864) 0.8889 162/74 1.317 (0.711–2.438) 0.3808
 2 or more 172/200 1 618/573 1.024 (0.802–1.308) 0.8464 320/234 1.122 (0.841–1.496) 0.4342
Age at first birth (yr)
 < 28 133/144 1 394/387 0.949 (0.712–1.265) 0.7217 164/153 0.907 (0.637–1.292) 0.5897
 ≥ 28 69/79 1 398/298 1.199 (0.826–1.742) 0.3395 315/155 1.546 (1.035–2.310) 0.0333
Family history of breast cancer
 No 163/212 1 719/671 1.051 (0.825–1.338) 0.6884 473/349 1.052 (0.801–1.380) 0.7164
 1st degree 37/24 1 143/80 1.156 (0.632–2.112) 0.6379 85/30 1.890 (0.921–3.880) 0.0827

BI-RADS, Breast Imaging-Reporting and Data System.

Adjusted for body mass index, smoke, drink duration, exercise, age, age at menarche, age at menopause, number of child, number of first-degree relatives with breast cancer.

J Cancer Prev 2019;24:26-32 https://doi.org/10.15430/JCP.2019.24.1.26
© 2019 J Cancer Prev