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Table. 3.

Table. 3.

ORs and 95% CIsa of breast cancer for selected risk factors by breast density groups and their interaction effects

Variable BI-RADS 1 and 2 (< 50%) BI-RADS 3 (50%–75%) BI-RADS 4 (≥ 75%) P-interaction



No. of case/control OR (95% CI) P-value No. of case/control OR (95% CI) P-value No. of case/control OR (95% CI) P-value
Age at menarche (yr)
 < 15 118/99 1.176 (0.765–1.809) 0.46 658/442 1.375 (1.103–1.715) 0.0047 502/276 1.528 (1.113–2.096) 0.0086 0.6806
 ≥ 15 93/136 1 281/322 1 123/120 1
Age at menopause (yr)
 Premenopausal 59/42 1 548/380 1 511/310 1 0.9109
 < 50 65/93 1.621 (0.822–3.195) 0.1633 199/233 0.949 (0.710–1.267) 0.7211 69/65 0.858 (0.563–1.308) 0.4767
 ≥ 50 92/135 1.746 (0.852–3.577) 0.128 209/248 1.092 (0.794–1.501) 0.5899 51/55 0.865 (0.513–1.458) 0.5855
Number of children
 0 10/10 0.547 (0.195–1.532) 0.251 146/60 1.823 (1.287–2.582) 0.0007 143/72 1.085 (0.747–1.576) 0.6676
 1 30/32 0.771 (0.424–1.403) 0.3947 175/127 1.141 (0.868–1.499) 0.3439 162/74 1.442 (1.027–2.023) 0.0344 0.0921
 2 or more 172/200 1 618/573 1 320/234 1
Age at first birth (yr)
 < 28 133/144 1 394/387 1 164/153 1 0.0048
 ≥ 28 69/79 0.781 (0.493–1.236) 0.2904 398/298 1.087 (0.865–1.365) 0.4734 315/155 1.627 (1.190–2.226) 0.0023
Family history of breast cancer
 No 163/212 1 719/671 1 473/349 1 0.7925
 1st degree 37/24 2.140 (1.158–3.954) 0.0152 143/80 1.653 (1.215–2.249) 0.0014 85/30 1.690 (1.064–2.685) 0.0261

BI-RADS: Breast Imaging-Reporting and Data System.

Adjusted for body mass index, smoke, drink duration, exercise, age, age at menarche, age at menopause, number of child, number of first-degree relatives with breast cancer.

J Cancer Prev 2019;24:26-32 https://doi.org/10.15430/JCP.2019.24.1.26
© 2019 J Cancer Prev