Journal of Cancer Prevention : pISSN 2288-3649 / eISSN 2288-3657

Fig. 1.

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Fig. 1. The structural classification of tripartite motif (TRIM) family proteins. Most of TRIM proteins contain a really interesting new gene (RING) finger domain, one or two B-box domain (B1 and B2) and a coiled-coil (CC) domain in N-terminal region. TRIM proteins are classified into 11 subfamilies (C-I to C-XI) based on a variable C-terminal domain. There is an additional unclassified group lacking a RING finger domain (No RING). Some TRIM family members lack one or more domain as denoted in brackets and by a dashed outline. TRIM proteins described in this review are in bold. Pyrin, Pyrin domain; COS, cos-box; FN3, fibronectin type III repeat; PRY, PRY domain; SPRY, SPRY domain; ACID, acid-rich region; PHD, PHD domain; BROMO, bromodomain; FIL, filamin-type immunoglobulin domain; NHL, NCL1, HT2A and LIN41 domain; MATH, meprin and TRAF-homology domain; ARF, ADP-ribosylation factor family domain; TM, transmembrane region.
Journal of Cancer Prevention 2018;23:162-9
© 2018 Journal of Cancer Prevention