Journal of Cancer Prevention : pISSN 2288-3649 / eISSN 2288-3657

Fig. 1.

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Fig. 1. Schematic diagram of proteasome structure and ubiquitination process. The 26S proteasome is a complex of multiple subunits consisting of 20S proteasomes (two α-subunits and two β-subunits) and two 19S regulatory particles (RP). Seven a-subunits act as a gate to 20S proteasome, and three subunits (β1, β2, and β5) of the seven β-subunits have protease activity to degrade substrate proteins. Rpn1, 10, and 13 in the lid region recognize and bind with ubiquitin bound to substrate protein, resulting in unfolding and translocation of substrate protein by Rpt1–6 with ATPase activity. Rpt2, 3, and 5 open 20S proteasome gates to allow the degradation of substrate protein via 20S proteasome.
Journal of Cancer Prevention 2018;23:153-61 https://doi.org/10.15430/JCP.2018.23.4.153
© 2018 Journal of Cancer Prevention