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Journal of Cancer Prevention
Journal of Cancer Prevention : pISSN 2288-3649 / eISSN 2288-3657

Fig. 3.

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Fig. 3. Carcinogenic adverse outcome pathway (AOP) examples. (A) The graphical representation of AOP 46 is adopted from the AOP-Wiki (https://aopwiki.org/aops/46). This AOP illustrates the process by which aflatoxin B1 (AFB1) causes hepatocellular carcinoma at various levels of biological organization. (B) The graphical representation of AOP 220 is adopted from the AOP-Wiki (https://aopwiki.org/aops/220). This AOP illustrates the process of liver cancer caused by the chronic activation of CYP2E1 at various levels of biological organization. MIE, molecular initiating event; KER, key event relationship; KE, key event; AO, adverse outcome; AHF, Altered Hepatic Foci.
Journal of Cancer Prevention 2018;23:126-33 https://doi.org/10.15430/JCP.2018.23.3.126
© 2018 Journal of Cancer Prevention

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