Journal of Cancer Prevention : pISSN 2288-3649 / eISSN 2288-3657

Fig. 2.

Download original image
Fig. 2. Schematic adverse outcome pathway (AOP) framework. (A) The AOP consist of a molecular initiating event (MIE), key event (KE), key event relationship (KER), and an adverse outcome (AO). Arrows indicate KERs and a dotted arrow is the naKER, that is, the non-adjacent (indirect) KER. Basically, a KER is the relationship between the two adjacent KEs, but the relationship between non-adjacent KEs is also possible. One AOP has one MIE and AO, and there is no limit to the number of KE and KER. (B) Since each component of an AOP exists independently, even different AOPs can contain the same component. Arrows also mean KER and the indication is omitted for convenience.
Journal of Cancer Prevention 2018;23:126-33
© 2018 Journal of Cancer Prevention