Journal of Cancer Prevention : pISSN 2288-3649 / eISSN 2288-3657

Fig. 2.

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Fig. 2. Signaling pathways involving PIM kinase. Up-stream target proteins of PIM (proviral integration site for moloney murine leukemia virus) kinase are janus kinase/signal transducers and activators of transcriptions (JAK/STATs) and their activations cause to stimulate PIM kinase. Activated PIM kinase boosts its downstream signaling targets, such as myelocytomatosis (MYC), BCL-2-associated agonist of cell death (BAD), p21Cip1/Waf1/p27Kip1, and cell devision cycle 25 (CDC25), and regulates gene transcription, cell cycle progression, and apoptosis.
Journal of Cancer Prevention 2018;23:109-16
© 2018 Journal of Cancer Prevention