Journal of Cancer Prevention : pISSN 2288-3649 / eISSN 2288-3657

Table. 1.

Table. 1.

Role of aberrantly deregulated RBPs in human cancers

Cancer HallmarkRBPTarget mRNAsCancer typesReference number
Sustained proliferationESRP1/2CCND1, CDH1, CDKN1A, MYC, PKM2,Colon28, 29
IGF2BP3MYC, CDK6Leukemia30
LIN28A/BBMP4, HER2, HMGA1Breast, ovary, liver, colon31, 32
QKICDKN1B, FOS, miR-20a, NUMBBrain, colon, lung33, 34
HuRCCNA2, CCNB1Gastric, breast35, 36
SAM68CD44, CCND1Prostate, breast37, 38
Evading apoptosishnRNPHMADD, RONBrain39
LARP4BBCL2, BIK, BAX, XIAPBrain40, 41
eIF4EBCL2, BCL-XLLymphoma42
TIA1/TIARGADD45A, FAS, PDCD4Multiple43, 44
CELF1BAD, BAX, JunDOral45
Inducing angiogenesisRBP2CDKIGastric46
HuRVEGF, HIF-1α, THBS1Breast, brain47, 48
LARP6VEGFBreast49
eIF4EVEGF, FGF-2, PDGFMultiple50, 51
Activating EMT and metastasisIGF2BPsCD164, PDPN, CD44, IGF2, MMP9Breast, colon, leukemia5254
hnRNPE1DAB2, ILE1Breast, ovary27
UNR/CSDE1VIM, RAC1Melanoma13
RBM47CUL3, DKK1, MDM4, MXI1, SLKBreast, lung55
Avoiding immune surveillanceIGF2BP3ULPB2, MICBLeukemia56
LIN28Let-7Leukemia57, 58
FXR1PRKCI, ECT2Lung59, 60

RBP, RNA binding protein; EMT, epithelial-mesenchymal transition; ESRP1/2, epithelial splicing regulatory protein 1 and 2; IGF2BP3, insulin-like growth factor 2 mRNA-binding protein 3; QKI, protein quaking; HuR, Hu antigen R; SAM68, Src-associated protein in mitosis of 68 kDa; LARP4B, La ribonucleoprotein domain family member 4B; eIF4E, eukaryotic initiation factor 4E; TIA1, T cell intracellular antigen 1; CELF1, CUGBP, elav-like family member 1; RBP2, retinol binding protein 2; UNR/CSDE1, upstream of N-Ras/Cold shock domain-containing protein E1; RBM47, RNA binding motif protein 47; FXR1, fragile X-related 1.

Journal of Cancer Prevention 2017;22:203-10 https://doi.org/10.15430/JCP.2017.22.4.203
© 2017 Journal of Cancer Prevention