Fig. 4. Pathway analysis of nickel toxicity. The analyzed data showed the potentials of genomic interaction, cellular processes, and diseases induced by exposure of nickel. 15 proteins, 8 cellular processes, 15 diseases, 1 small molecule and 1 functional class appeared in figure. ROS, reactive oxygen species; TLR4, toll-like receptor 4; MAPK, mitogen-activated protein kinase; NDRG1, N-myc downstream regulated 1; CAT, catalase; TP53, tumor protein 53; ICAM1, Intercellular adhesion molecule 1; JUN, Jun proto-oncogene; SERPINE1, serine peptidase inhibitor, clade E, member 1; IL, interleukin; BCL2, B cell lymphoma 2 protein; FOS, Finkel-Biskis-Jinkins murine osteosarcoma viral oncogene homolog; CDH1, cadherin 1.

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