Journal of Cancer Prevention

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Fig. 2. Common molecular mechanisms of endocrine disruptors. (A) Endocrine disruptors act as receptors (especially endocrine receptor) binding inhibitors. Most harmful effects are initiated by this inhibition and is shown by most endocrine disruptors mechanism. (B) When the targets of endocrine disruptors were adipocyte, endocrine disruptors can be obesogens. In this case, peroxisome proliferator activated receptor (PPAR) on mesenchymal cells or progenitor cells are the targets. (C) In the case of cancer, endocrine disruptors act on the cell cycle. Cyclin protein and p21 protein were known to regulate cancer cells when exposed to endocrine disruptors. ER, estrogen receptor; MSC, mesenchymal stem cell. Cited from the article of Celik et al. (Chem Res Toxicol 2008;21:2195-206), Masuno et al. (Toxicol Sci 2005;84:319-27), and Ohtsubo et al. (Mol Cell Biol 1995;15:2612-24).16-18
Journal of Cancer Prevention 2015;20:12~24 https://doi.org/10.15430/JCP.2015.20.1.12
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